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Side Effects: Excessive doses may cause neuromuscular weakness and, in severe cases, respiratory arrest, particularly when administered rapidly by infusion

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In its most recent publication on smoking, the World Health Organization pointed out that, among the eight main causes of death in the world today, six are associated with tobacco exposure, among them we stress inflammatory and infectious diseases of the respiratory tract.1 According to data from the Ministry of Health (2006), 16.2% of the adult Brazilian population smoke cigarettes daily.2 Despite the broad advertisement in the media about the harmful effects of cigarette smoking, very little is known about the association between cigarette exposure and the development of associated disorders such as chronic rhinosinusitis (CR)